Below you will find pages that utilize the taxonomy term “Storage”
Vitamins
read more
Calcifediol
[Vitamin D](vitamin-d), also called calcifediol (the short-term storage form), is made in the liver from another form of vitamin D. It usually binds to a protein in the blood, which helps it stay in the body for weeks. If there's not enough of this protein, vitamin D can be broken down and removed from the body through the kidneys. When the body needs more of the active form of vitamin D (/vitamins/vitamin-d/calcitriol), especially for things like low calcium or immune system support, stored vitamin D is quickly converted.
[Vitamin D](vitamin-d) levels in the blood can indicate if someone has a deficiency or not. If levels are too low (see table below), the body may struggle to make enough active vitamin D, leading to various diseases.
For more technical details, read on.
The name Calcifediol (aka vitamin D) refers to a hormone that is produced via hydroxylation of Cholecalciferol in the human liver. Calcifediol is typically bound to the D-binding protein (DBP) but can be unbound if there is not enough DBP. If unbound, it is typically degraded and excreted via the kidneys. When bound to DBP, Calcifediol is relatively stable and can circulate in the human blood for weeks. Unless it is converted to Calcitriol and used by downstream processes. If demand for Calcitriol is high, e.g., low calcium or challenges to the immune system, ‘stored’ Calcifediol is converted to Calcitriol quicker.