Below you will find pages that utilize the taxonomy term “D3”
Article Criticism (Focus Online)
Are you flushing money—and your health—down the drain
with vitamins? Stick around as we uncover shocking truths about a recent article on supplements that gets it all wrong! An article from Focus Online claims to reveal which vitamins are worth it and which are just making your urine expensive. But here’s the catch—it’s riddled with misinformation, outdated science, and alarmist advice. Let’s break it down!
Outdated Perspective on Nutritional Content
- Decreased Nutritional Value in Modern Foods: The article assumes a “well-balanced diet” today provides sufficient nutrients, but it ignores substantial research indicating that modern agricultural practices, soil depletion, and food processing have reduced the nutrient content of many foods compared to 50 years ago. For example:
- Evidence: Studies have documented declines in magnesium, calcium, and vitamins in crops due to soil depletion and high-yield cultivars (Mayer et al., 2021) and shifts from natural to chemical farming (Bhardwaj et al., 2024).
- Nutrient dilution occurs in crops bred for higher yields, reducing essential minerals in food (Davis, 2009).
Lack of References and Evidence
- No Scientific Citations: The article refers to studies and findings (e.g., a large US study, a metanalysis, and trials on Vitamin A or Vitamin E) but fails to provide proper citations or hyperlinks to these studies. This makes it impossible for readers to verify claims or delve deeper into the research.
- Unsubstantiated Claims: While it mentions potential harms of over-supplementation (e.g., increased cancer risk, kidney stones, or liver damage), these are anecdotal without detailed data or named studies.
- Generalizations like “Vitamin C doesn’t protect against colds” lack nuance. Specific research supports modest benefits of Vitamin C in reducing cold duration for certain populations and related to that also improved recovery from severe physical exercise Hemilä and Chalker, 2013.
Misrepresentation of Vitamin B12
- B12 Source Error: The article perpetuates a common misconception by implying that animal products are the “natural” source of Vitamin B12. In reality, Vitamin B12 is produced exclusively by bacteria and archaea, not animals Fang et al., 2017. Animals accumulate B12 by consuming bacteria-laden soil, water, or through bacterial synthesis in their digestive systems. This point is particularly relevant for:
- Modern farming practices that eliminate natural exposure to bacteria (e.g., sterilized feed and water), often necessitating the fortification of animal feed with synthetic B12.
- Plant-based eaters who may miss out on B12 due to the lack of natural bacterial sources in modern, sanitized food systems.
- In summary, the more contaminated our food is with bacteria, the higher the B12 amount in the food. It could make one cringe to hear that animal products are high in B12 (from fecal contamination during processing?).
- Misleading Statement on Veganism: While the article acknowledges that vegans require B12 supplementation, it oversimplifies the issue by ignoring that even non-vegans can be at risk. For instance:
- Older adults often experience reduced B12 absorption due to lower stomach acid production, regardless of diet. Evidence: Absorption issues affect over 20% of adults over 60 (Hepperly & Seidel, 2018).
- Individuals with gastrointestinal disorders (e.g., Crohn’s disease or celiac disease) or those on certain medications (e.g., proton-pump inhibitors) may also struggle to absorb B12.
- Fun fact: Bacteria in the human gut also produce Vitamin B12. Unfortunately, it is produced too far down in the gut, and we cannot take it up from the gut anymore.
Failure to Address Real-World Dietary Challenges
- Lifestyle and Accessibility: The article doesn’t consider the challenges many people face in consistently achieving a “well-balanced” diet:
- Time constraints and socioeconomic factors often lead to reliance on processed foods, which may lack sufficient micronutrients.
- Seasonal availability of fresh produce can impact dietary diversity and nutrient intake.
- Individual Variability: It fails to address how individual metabolic and genetic factors (e.g., MTHFR gene mutations affecting folate metabolism) may necessitate supplementation for optimal health, even in those eating varied diets.
- A global meta-analysis highlights the widespread deficiencies of essential nutrients like Vitamin A and folate Herrero et al., 2017.
Limited Relevance for Consumers
- Generalized Advice: Statements like “most people do not need supplements if they eat a balanced diet” are overly broad. They fail to address scenarios where individuals may have unique dietary restrictions, medical conditions, or lifestyle factors that necessitate supplementation.
- Lack of Clarity on Dosages: While the article warns about overdosage risks, it doesn’t provide actionable details such as safe dosage ranges, nor does it refer to official recommendations like those from the EFSA (European Food Safety Authority) or BfR (German Federal Institute for Risk Assessment).
- Simplistic Categorization: Grouping vitamins into “good” and “bad” categories oversimplifies a complex topic. For example:
- Vitamin C is dismissed, but for individuals with specific deficiencies or increased needs (e.g., smokers or the elderly), supplementation might be warranted.
- Multivitamins are dismissed wholesale, ignoring specific populations who might benefit, like those with malabsorption issues.
Broader Context on Supplements
- General Criticism Without Nuance: While the article criticizes over-supplementation, it overlooks the critical role supplements can play in specific scenarios:
- Pregnancy, lactation, and aging increase nutrient requirements that may not always be met through food alone.
- Certain supplements, such as iodine in regions with low natural iodine in the soil, have been instrumental in addressing public health issues.
- Failure to Differentiate Synthetic vs. Natural Sources: For example:
- The efficacy and bioavailability of synthetic versus natural forms of vitamins (e.g., folic acid vs. methylfolate) are not discussed.
- A prominent example is Vitamin E, which is actually eight different compounds. One of them Alpha-tocopherol exists as one stereoisomer in nature but, when produced chemically, has several stereoisomers. Remember Contagan? The issue was that we couldn’t or didn’t separate the unnatural stereoisomers. Failure to understand such issues leads to severe outcomes (Contergan) or outcomes we do not yet understand (Vitamin E).
Missed Opportunities for Actionable Guidance
- No Practical Recommendations: The article fails to guide readers on identifying a potential deficiency or when to consult a doctor. For example, it could suggest regular blood tests to assess vitamin levels. Blood testing and physician consultations are recommended to avoid both deficiencies and excesses Example.
- Overlooked Populations: The nuanced needs of subpopulations (e.g., older adults, people with darker skin living in low-sunlight regions, or those with restrictive diets) are ignored. For instance, MTHFR mutations affect folate metabolism, requiring targeted intervention Zarembska et al., 2023.
Misleading and Alarmist Tone
- Fear-Based Messaging: The article leans heavily on scare tactics, such as phrases like “teuren Urin” (expensive urine) and “im schlimmsten Fall schaden” (worst case, harm your health). This tone can alienate readers rather than educate them.
- One-Sided Perspective: While it critiques unnecessary supplementation, it does not adequately acknowledge the prevalence of deficiencies in certain groups or provide balanced views on supplements’ potential benefits.
Suggestions for Improvement
To correct these issues, the article should:
Article Criticism (Brain Vitamin D Forms)
The Curious Case of Vitamin D and Brain Health: A Study Worth Revisiting
Recently, the German journal FITBOOK ran an article discussing a study that examined the relationship between Vitamin D levels in brain tissue and cognitive function. The FITBOOK piece itself was riddled with oversimplifications and exaggerations (which I’ve dissected elsewhere), but now it’s time to look critically at the study that sparked the excitement.
At first glance, the study appears to offer intriguing insights into Vitamin D’s potential role in brain health. Upon closer inspection, however, it falls short in several ways. Here’s a breakdown of the study’s key limitations and why its findings need to be taken with a hefty pinch of salt.
Article Criticism (FITBOOK Journal)
Response to an Article in German Journal FITBOOK
I commented earlier on another article in FITBOOK concerning the Amazing effect of vitamin D supplementation on metabolism. Now, we need to talk about another article in FITBOOK. The article entitled: “Effect of vitamin D on brain function” discusses a study on Brain Vitamin D Forms, Cognitive Decline and Neuropathology in Community-dwelling Older Adults. The article by Friederike Ostermeyer discusses a recent study examining the relationship between Vitamin D levels in the brain and cognitive function. While Vitamin D is undoubtedly important for overall health, her article exaggerates the findings of the study and misrepresents key points, leaving readers with more hype than substance.
Vitamin D Supplementation
Vitamin D, often called the “sunshine hormone,” plays a vital role in overall health. Many people in the Western world are deficient in it, but before deciding to supplement, it’s essential to test your blood levels (Calcifediol). This can help you understand whether supplementation is necessary and how much you need to reach optimal levels.
Key considerations include your current blood levels, lifestyle, UVB exposure, skin tone, BMI, and health conditions. Vitamin D3 (Cholecalciferol) is the preferred supplement form, as it is more effective than Vitamin D2. Individuals with higher BMIs or certain health conditions may require higher doses or specialized forms like Calcifediol or Calcitriol.
Article Criticism (FITBOOK Journal)
Response to an Article in German Journal FITBOOK
The article entitled: “Amazing effect of vitamin D supplementation on metabolism” discusses a recent study that according to the author of the FITBOOK article suggests supplementing 3320 IU of Vitamin D per day. Let’s clarify first that the study entitled: “Modifiers of the Effects of Vitamin D Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis” has been published in the journal of Engineering and is a meta-analysis, not a new research study.
Calciol Production
Cholecalciferol Production
When our skin is exposed to UVB rays, e.g., during sun exposure, Cholecalciferol aka Calciol is produced from 7-Dehydrocholesterol. In a 1977 publication, PC Beadle estimated that about 160 IU Cholecalciferol could be produced at 40° Latitude when exposing 1 $cm^{2}$ of skin to the sun for the whole day. Dark skin would produce around 70 IU under the same conditions. This information is suboptimal to drive the decision of how to expose oneself to the sun.
Vitamin D Unit Converter
Vitamin D (Cholecalciferol) used to be measured in micrograms (mcg). At one point, international units were introduced (IU). Today, either or both IU and mcg are found on supplement labels. Sometimes, it is beneficial to know the amount in IU and the amount in mcg. Especially when you want to use the correct ratio of several vitamins simultaneously. An important example in this context would be the combination of vitamin D and vitamin K. While Cholecalciferol ensures that there is enough calcium in the blood, vitamin K is involved in bringing calcium to the correct location (bones). Calcification of soft tissues such as cartilage and arteries is definitely something no one wants. Therefore, both vitamins should be used together. How much of each is a discussion for another time. However, once you decide and settle on a ratio between vitamins D and K, you can use the below converter to ensure that you use the correct amounts.
Sarcoidosis
Worldwide, this disease is relatively uncommon ranging from 1 to 80 cases per 100,000 people. The relationship to vitamin D is that in this condition large amounts of Calcitriol are produced bypassing the typical regulation controls.
Sarcoidosis is an inflammatory disease where granulomas (small clusters of immune cells) form in various organs, particularly the lungs and lymph nodes. In sarcoidosis, activated macrophages in these granulomas can convert Calcifediol to its active form, Calcitriol, independent of the body’s D3 regulation. This can lead to hypercalcemia (elevated calcium levels) and hypercalciuria (elevated calcium in urine). Hypercalcemia is an often cited reason for vitamin D toxicity. Clearly, in this case sarcoidosis is too blame and not vitamin D since the disease bypasses the regulatory mechanisms.
Vitamin D Regulation
Calcitriol, the active form of vitamin D, is a powerful hormone that needs tight regulation in the body. It acts like a “key” that fits into specific “locks” (receptors) to manage important functions like calcium and phosphate balance. Too much or too little can cause harm, so the body carefully controls how much is made.
The body converts stored vitamin D (Calcifediol) into Calcitriol in the kidneys, but if Calcitriol levels get too high, enzymes slow down its production and break it down. Calcium and phosphate levels in the blood also help regulate this process.
Low calcium triggers the production of more Calcitriol, while high calcium or phosphate slows it down. Additionally, low phosphate increases Calcitriol, while high phosphate decreases it. These processes work together to maintain balance, ensuring proper calcium and phosphate levels in the blood.
If vitamin D stores are low, the body can’t produce enough Calcitriol, which can lead to health problems.
Calcitriol
The name Calcitriol (aka vitamin D) refers to a hormone that is produced via hydroxylation of Calcifediol in the human liver. Calcitriol is typically bound by the D-binding protein (DBP) but has a lower affinity DBP than Calcifediol but higher than Cholecalciferol. Calcitriol is the active form of the hormone and facilitates calcium uptake among a myriad of other functions, such as immune system-related ones.
Calciol
Cholecalciferol
For more technical details, read on.
Calcifediol
The name Calcifediol (aka vitamin D) refers to a hormone that is produced via hydroxylation of Cholecalciferol in the human liver. Calcifediol is typically bound to the D-binding protein (DBP) but can be unbound if there is not enough DBP. If unbound, it is typically degraded and excreted via the kidneys. When bound to DBP, Calcifediol is relatively stable and can circulate in the human blood for weeks. Unless it is converted to Calcitriol and used by downstream processes. If demand for Calcitriol is high, e.g., low calcium or challenges to the immune system, ‘stored’ Calcifediol is converted to Calcitriol quicker.
Vitamin D Solubility
Vitamin D, in fact a hormone, is said to be soluble in fat. Therefore, it has been cautioned, that too large an intake or production of D3 or more precisely Cholecalciferol can be dangerous since it could be stored in fat. Solubility is not that easy, especially when considering biological systems. First of, anything is soluble in anything to a varying degree. When saying D3 is fat soluble, we also need to consider that there are three different molecules that we mean when we say D3 (see vitamin D for a disambiguation).
Vitamin D
Vitamin D, technically a hormone, is made in the skin when UVB rays convert a cholesterol compound into D3 (Cholecalciferol, or Calciol). Many people don’t make enough due to lack of sun exposure, so we rely on food (like fatty fish) or supplements. Plants provide D2 (Ergocalciferol), but D3 works better in our bodies.
D3 has three key forms:
- Calciol: Stored in fat for long-term use; this is the form we produce or ingest.
- Calcifediol: Formed in the liver for short-term storage, circulating in blood and commonly tested to check D3 levels.
- Calcitriol: The active form, made in the kidneys, with a short lifespan but crucial for biological effects.
We’ll be using the terms Calciol → Calcifediol → Calcitriol throughout future discussions.