Below you will find pages that utilize the taxonomy term “Cholecalciferol”
Vitamin D Supplementation
Vitamin D, often called the “sunshine hormone,” plays a vital role in overall health. Many people in the Western world are deficient in it, but before deciding to supplement, it’s essential to test your blood levels (Calcifediol). This can help you understand whether supplementation is necessary and how much you need to reach optimal levels.
Key considerations include your current blood levels, lifestyle, UVB exposure, skin tone, BMI, and health conditions. Vitamin D3 (Cholecalciferol) is the preferred supplement form, as it is more effective than Vitamin D2. Individuals with higher BMIs or certain health conditions may require higher doses or specialized forms like Calcifediol or Calcitriol.
Calciol Production
Cholecalciferol Production
When our skin is exposed to UVB rays, e.g., during sun exposure, Cholecalciferol aka Calciol is produced from 7-Dehydrocholesterol. In a 1977 publication, PC Beadle estimated that about 160 IU Cholecalciferol could be produced at 40° Latitude when exposing 1 $cm^{2}$ of skin to the sun for the whole day. Dark skin would produce around 70 IU under the same conditions. This information is suboptimal to drive the decision of how to expose oneself to the sun.
Calciol
Cholecalciferol
For more technical details, read on.
Vitamin D
Vitamin D, technically a hormone, is made in the skin when UVB rays convert a cholesterol compound into D3 (Cholecalciferol, or Calciol). Many people don’t make enough due to lack of sun exposure, so we rely on food (like fatty fish) or supplements. Plants provide D2 (Ergocalciferol), but D3 works better in our bodies.
D3 has three key forms:
- Calciol: Stored in fat for long-term use; this is the form we produce or ingest.
- Calcifediol: Formed in the liver for short-term storage, circulating in blood and commonly tested to check D3 levels.
- Calcitriol: The active form, made in the kidneys, with a short lifespan but crucial for biological effects.
We’ll be using the terms Calciol → Calcifediol → Calcitriol throughout future discussions.